Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30234442 | 0.76 | CTSV (0.36) | LMNACTSLALDH1A1SMN1; SMN2 | |
| SCHEMBL23883949 | 0.76 | CTSV (0.36) | LMNACTSLALDH1A1SMN1; SMN2 | |
| SCHEMBL21900949 | 0.75 | HDAC1 (0.34) | GRM5MAPK14MAPK10MAPK8 | |
| SCHEMBL21900948 | 0.74 | CDC7 (0.41) | GRM5HTR2ARAB9ANPC1 | |
| SCHEMBL29536029 | 0.74 | CDC7 (0.41) | GRM5HTR2ARAB9ANPC1 | |
| SCHEMBL22688397 | 0.73 | LRRK2 (0.38) | GRM5MAPK14MAPK10MAPK8HTR2A | |
| SCHEMBL30234541 | 0.72 | CASP3 (0.35) | GRM5MAPK14MAPK10MAPK8MAPT | |
| SCHEMBL23883846 | 0.72 | CASP3 (0.35) | GRM5MAPK14MAPK10MAPK8MAPT | |
| SCHEMBL23884018 | 0.72 | CTSV (0.37) | GRM5HTR2ACTSLALDH1A1 | |
| SCHEMBL30235230 | 0.72 | CTSV (0.37) | GRM5HTR2ACTSLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |