Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 8/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 8/20 | 0.39 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28266976 | 0.98 | PSMB8 (0.41) | P2RX7PSMB8PSMB5PSMB9SMYD3 | |
| SCHEMBL18367737 | 0.96 | PSMB8 (0.43) | P2RX7PSMB8PSMB5PSMB9SMYD3 | |
| SCHEMBL15331115 | 0.86 | P2RX7 (0.38) | P2RX7PSMB8PSMB5SMYD3DRD2 | |
| Hydrochloric Acid SCHEMBL22533025 | 0.84 | P2RX7 (0.37) | P2RX7PSMB8PSMB5SMYD3DRD2 | |
| SCHEMBL18367749 | 0.84 | P2RX7 (0.37) | P2RX7SMYD3DRD2DRD4KCNH2 | |
| SCHEMBL4963807 | 0.81 | KDM2A (0.42) | P2RX7PSMB8PSMB5SMYD3DRD2 | |
| SCHEMBL21774861 | 0.78 | SMYD3 (0.50) | P2RX7PSMB8PSMB5PSMB9SMYD3 | |
| SCHEMBL21774864 | 0.78 | SMYD3 (0.50) | P2RX7PSMB8PSMB5PSMB9SMYD3 | |
| SCHEMBL28909869 | 0.77 | SMYD3 (0.38) | P2RX7PSMB8PSMB5PSMB9SMYD3 | |
| SCHEMBL28909867 | 0.77 | SMYD3 (0.38) | P2RX7PSMB8PSMB5PSMB9SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4370515-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | Incyte Corporation (US) | 2024-05-22 | — | — | EP | disclosed |
| WO-2023287896-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-19 | — | — | WO | disclosed |