Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2A | Q9Y2K7 | 10/20 | 0.42 |
| ▸ | KDM5C | P41229 | 10/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.42 |
| ▸ | KDM6B | O15054 | 6/20 | 0.42 |
| ▸ | KDM4A | O75164 | 4/20 | 0.42 |
| ▸ | KDM3A | Q9Y4C1 | 6/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30182247 | 0.81 | P2RX7 (0.42) | P2RX7DRD2DRD4KCNH2SIGMAR1 | |
| SCHEMBL22532671 | 0.80 | KDM2A (0.35) | KDM2AKDM5CKDM4CKDM6BKDM4A | |
| SCHEMBL18367749 | 0.80 | P2RX7 (0.37) | KDM2AKDM5CKDM4CKDM6BKDM4A | |
| SCHEMBL28266976 | 0.79 | PSMB8 (0.41) | P2RX7DRD2DRD4KCNH2SIGMAR1 | |
| SCHEMBL16717256 | 0.79 | KDM5C (0.43) | KDM2AKDM5CKDM4CKDM6BKDM4A | |
| SCHEMBL16399950 | 0.79 | KDM5A (0.51) | KDM2AKDM5CKDM4CKDM6BKDM4A | |
| SCHEMBL18375758 | 0.78 | SMN1; SMN2 (0.55) | KDM2AKDM5CKDM3A | |
| SCHEMBL18367737 | 0.78 | PSMB8 (0.43) | P2RX7DRD2DRD4KCNH2SIGMAR1 | |
| SCHEMBL21774861 | 0.77 | SMYD3 (0.50) | KDM2AKDM5CKDM4CKDM6BKDM4A | |
| SCHEMBL21774864 | 0.77 | SMYD3 (0.50) | KDM2AKDM5CKDM4CKDM6BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020070332-A1 | OXINDOLE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | ICHNOS SCIENCES S.A. (CH) | 2020-04-09 | — | — | WO | disclosed |
| EP-1888529-A2 | 3-CYANOQUINOLINE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME | Wyeth (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006124692-A2 | 3-CYANOQUINOLINE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |