SCHEMBL30183010

SCHEMBL30183010

Cc1cccc(-c2[nH]c(N)nc2-c2ccc3c(cnn3C)c2)n1

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 19/20 0.65
MAPK14 Q16539 7/20 0.65
CYP1A2 P05177 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30182848 0.93 TGFBR1 (0.63) TGFBR1MAPK14CYP1A2
SCHEMBL30855659 0.86 TGFBR1 (0.64) TGFBR1MAPK14CYP1A2
SCHEMBL30182822 0.85 TGFBR1 (0.65) TGFBR1MAPK14CYP1A2
SCHEMBL28510134 0.85 TGFBR1 (0.63) TGFBR1MAPK14CYP1A2
SCHEMBL29281241 0.84 TGFBR1 (0.48) TGFBR1MAPK14CYP1A2
SCHEMBL30855626 0.84 CYP1A2 (0.64) TGFBR1MAPK14CYP1A2
SCHEMBL30855651 0.83 TGFBR1 (0.48) TGFBR1MAPK14CYP1A2
SCHEMBL28516353 0.82 TGFBR1 (0.60) TGFBR1MAPK14CYP1A2
SCHEMBL29281213 0.82 TGFBR1 (0.49) TGFBR1MAPK14CYP1A2
SCHEMBL30182812 0.81 TGFBR1 (0.44) TGFBR1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4384511-A1 FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF Bisichem Co., Ltd. (KR) 2024-06-19 EP disclosed
CN-117881669-A Condensed ring heteroaryl compounds and uses thereof 比西切姆有限公司 2024-04-12 CN disclosed
WO-2023018313-A1 FUSED RING HETEROARYL COMPOUNDS AND USE THEREOF BISICHEM CO., LTD. (KR) 2023-02-16 WO disclosed