Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018340 | 1.00 | GRIN1 (0.48) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3018338 | 1.00 | GRIN1 (0.48) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3024576 | 0.91 | S1PR5 (0.47) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3024572 | 0.91 | S1PR5 (0.47) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3024467 | 0.91 | S1PR5 (0.47) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3024463 | 0.91 | S1PR5 (0.47) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3024468 | 0.91 | S1PR5 (0.47) | GRIN1GRIN2BS1PR5NPC1RAB9A | |
| SCHEMBL3031744 | 0.78 | MAOB (0.46) | GRIN1GRIN2BMAOAMAOBHRH3 | |
| SCHEMBL3031740 | 0.78 | MAOB (0.46) | GRIN1GRIN2BMAOAMAOBHRH3 | |
| SCHEMBL3031742 | 0.78 | MAOB (0.46) | GRIN1GRIN2BMAOAMAOBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210680-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210680-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | TPH1, HTR2C, TPH2 | GRIN1 272/4885GRIN2B 151/4885S1PR5 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.