Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379160 | 0.89 | LMNA (0.49) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL303264 | 0.87 | LMNA (0.51) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL302902 | 0.86 | LMNA (0.51) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL301861 | 0.86 | LMNA (0.49) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL2187839 | 0.85 | HTT (0.48) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL301955 | 0.84 | LMNA (0.49) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL2246857 | 0.83 | MEN1 (0.65) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL301954 | 0.83 | LMNA (0.46) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL3379961 | 0.83 | LMNA (0.47) | LMNAHTTNPSR1MEN1KMT2A | |
| SCHEMBL2188728 | 0.82 | SPR (0.49) | LMNAHTTNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |