Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 8/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.47 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671667 | 1.00 | MAP2K4 (0.47) | MAP2K4MAPK1MAPK6CA12CA1 | |
| SCHEMBL2671776 | 0.88 | MAP2K4 (0.50) | MAP2K4MAPK1MAPK6CA12CA1 | |
| SCHEMBL30189210 | 0.88 | MAP2K4 (0.50) | MAP2K4MAPK1MAPK6CA12CA1 | |
| SCHEMBL4137466 | 0.84 | ACACB (0.44) | MAP2K4MAPK1ACACBACACARAB9A | |
| SCHEMBL4402972 | 0.84 | MEN1 (0.45) | MAP2K4MAPK1KDM4ETDP1ACACB | |
| SCHEMBL1144879 | 0.79 | DYRK1A (0.52) | MAP2K4MAPK1MAPK6MAPKAPK5MAPKAPK3 | |
| SCHEMBL31746650 | 0.79 | DYRK1A (0.52) | MAP2K4MAPK1MAPK6MAPKAPK5MAPKAPK3 | |
| SCHEMBL14038753 | 0.79 | KDR (0.41) | MAPK1 | |
| SCHEMBL1574004 | 0.77 | MAP2K4 (0.59) | MAP2K4MAPK1MAPK6CA12CA1 | |
| SCHEMBL922195 | 0.77 | PDPK1 (0.53) | MAP2K4MAPK1MAPK6MAPKAPK5ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |