Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.50 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671776 | 1.00 | MAP2K4 (0.50) | MAP2K4MAPK1MAPK6MAPKAPK3PRKAG1 | |
| SCHEMBL2671667 | 0.88 | MAP2K4 (0.47) | MAP2K4MAPK1MAPK6MAPKAPK3PRKAG1 | |
| SCHEMBL30189262 | 0.88 | MAP2K4 (0.47) | MAP2K4MAPK1MAPK6MAPKAPK3PRKAG1 | |
| SCHEMBL29301471 | 0.86 | KDM4E (0.50) | MAP2K4KDM4EALDH1A1HPGDCA1 | |
| SCHEMBL30147526 | 0.84 | CCNC (0.50) | LRRK2JAK2JAK1 | |
| SCHEMBL4404504 | 0.84 | MEN1 (0.45) | MAP2K4MAPK1MAPK6MAPKAPK3PRKAG1 | |
| SCHEMBL10242014 | 0.84 | ACACB (0.44) | MAP2K4MAPK1MAPK6MAPKAPK3PRKAG1 | |
| SCHEMBL31504557 | 0.79 | MAP2K4 (0.57) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL1145076 | 0.79 | MAP2K4 (0.57) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E | |
| SCHEMBL2671070 | 0.77 | MAP2K4 (0.55) | MAP2K4MAPK1MAPK6MAPKAPK3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149945-A1 | SUBSTITUTED TRICYCLIC AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2023-03-22 | — | — | EP | disclosed |