Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22229560 | 1.00 | ROCK2 (0.52) | ROCK2ROCK1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL30189509 | 0.91 | ROCK2 (0.42) | ROCK2ROCK1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL22229632 | 0.91 | ROCK2 (0.42) | ROCK2ROCK1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL22229650 | 0.90 | ROCK2 (0.43) | ROCK2ROCK1DYRK1A | |
| SCHEMBL30189463 | 0.90 | ROCK2 (0.43) | ROCK2ROCK1DYRK1A | |
| SCHEMBL22229642 | 0.90 | ROCK2 (0.41) | ROCK2ROCK1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL30189468 | 0.90 | ROCK2 (0.41) | ROCK2ROCK1CYP1A2CYP1A1CYP1B1 | |
| SCHEMBL22229639 | 0.88 | ROCK2 (0.39) | ROCK2ROCK1MAP4K4PRKACADYRK1A | |
| SCHEMBL30189454 | 0.88 | ROCK2 (0.39) | ROCK2ROCK1MAP4K4PRKACADYRK1A | |
| SCHEMBL22229637 | 0.87 | ROCK2 (0.46) | ROCK2ROCK1KDM4EDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542256-B2 | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors | ANGION BIOMEDICA CORP. (US) | 2023-01-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11542256-B2 | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885CYP1A2 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.