Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21379482 | 1.00 | MAPT (0.44) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL10466139 | 0.73 | RAB9A (0.46) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL19782941 | 0.67 | MEN1 (0.71) | MAPTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL10467190 | 0.67 | RAB9A (0.42) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL12426372 | 0.66 | SMN1; SMN2 (0.54) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2813561 | 0.66 | MAPT (0.34) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2970916 | 0.65 | TSHR (0.67) | RAB9ANPC1SMN1; SMN2LMNAGAA | |
| SCHEMBL1465687 | 0.63 | RAB9A (0.49) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL1703978 | 0.63 | RAB9A (0.68) | MAPTRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2812134 | 0.63 | KMT2A (0.50) | MAPTRAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |