Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAOB | P27338 | 7/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933207 | 1.00 | MAPT (0.68) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL29521387 | 0.86 | ROCK2 (0.64) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL122504 | 0.86 | ROCK2 (0.64) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL29365815 | 0.84 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL260992 | 0.84 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL21004185 | 0.83 | MAOB (0.52) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL25436298 | 0.82 | KDM4E (0.50) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL475069 | 0.82 | AR (0.63) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| Hydrochloric Acid SCHEMBL7001071 | 0.82 | ALDH1A1 (0.55) | MAPTKDM4EALDH1A1MAOBDYRK1A | |
| SCHEMBL20187143 | 0.82 | MAOB (0.58) | MAPTKDM4EALDH1A1MAOBDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773102-B2 | Heterocyclic compounds as PI3K-γ inhibitors | INCYTE CORPORATION (US) | 2023-10-03 | — | — | US | disclosed |
| US-20230009843-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773102-B2 | Heterocyclic compounds as PI3K-γ inhibitors | PIK3CD, PIK3CG, PIK3R5 | MAPT 3548/4885KDM4E 3824/4885ALDH1A1 2699/4885 |
| US-20230009843-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | PIK3R5, PIK3CA, PIK3CD | MAPT 3639/4885KDM4E 2567/4885ALDH1A1 3638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.