SCHEMBL30197605

SCHEMBL30197605

Fc1ccc(-c2nc(-c3ccccc3F)[nH]c2-c2ccncc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 15/20 1.00
CSNK1D P48730 6/20 1.00
CSNK1E P49674 5/20 1.00
MAPK13 O15264 11/20 0.77
GCGR P47871 11/20 0.77
MAPK12 P53778 11/20 0.77
MAPK11 Q15759 11/20 0.77
ALOX5 P09917 7/20 0.77
PRKD3 O94806 2/20 0.72
MAP4K4 O95819 2/20 0.72
FRK P42685 2/20 0.72
MAPK9 P45984 2/20 0.72
CSNK1A1 P48729 2/20 0.72
GSK3B P49841 2/20 0.72
PTK6 Q13882 2/20 0.72
CLK4 Q9HAZ1 2/20 0.72
PRKD2 Q9BZL6 1/20 0.72
TEK Q02763 1/20 0.66
KDM4E B2RXH2 1/20 0.64
CIT O14578 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17002317 1.00 MAPK14 (1.00) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL19813148 0.89 MAPK14 (0.80) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL17002223 0.87 MAPK14 (0.77) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL6450700 0.87 MAPK14 (0.77) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL17002225 0.87 MAPK14 (0.77) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL4563107 0.87 ALOX5 (1.00) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL6003680 0.87 MAPK14 (1.00) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL2650029 0.86 MAPK14 (1.00) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL17002226 0.85 MAPK14 (1.00) MAPK14CSNK1DCSNK1EMAPK13GCGR
SCHEMBL6449484 0.85 MAPK14 (0.73) MAPK14CSNK1DCSNK1EMAPK13GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024171957-A1 TRANSPLANTATION OF PITUITARY HORMONE-PRODUCING CELLS 国立大学法人東海国立大学機構 2024-08-22 WO disclosed
CN-118318033-A Cell aggregate comprising pituitary hormone-producing cells and method for producing the same 住友制药株式会社 2024-07-09 CN disclosed
CN-118043447-A Method for preparing cell population containing pituitary tissue and cell population 住友化学株式会社 2024-05-14 CN disclosed
EP-4172314-A1 CULTURE OF ORGANOIDS Genome Research Limited (GB) 2023-05-03 EP disclosed
WO-2023054395-A1 CELL AGGREGATE INCLUDING PITUITARY HORMONE-PRODUCING CELLS AND METHOD FOR PRODUCING SAME 住友ファーマ株式会社 2023-04-06 WO disclosed
WO-2023054396-A1 METHOD FOR PRODUCING CELL MASS INCLUDING PITUITARY TISSUE AND CELL MASS 住友化学株式会社 2023-04-06 WO disclosed
WO-2023277135-A1 METHOD FOR PRODUCING CELLS CONSTITUTING NASAL EPITHELIUM, AND CELL POPULATION INCLUDING CELLS CONSTITUTING NASAL EPITHELIUM OR PROGENITOR CELLS THEREOF 住友化学株式会社 2023-01-05 WO disclosed