⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1358313 | 0.85 | LRRK2 (0.40) | — | |
| SCHEMBL26388379 | 0.82 | CYP17A1 (0.38) | — | |
| SCHEMBL19504916 | 0.77 | — | — | |
| SCHEMBL6154188 | 0.76 | CYP1A2 (0.33) | — | |
| SCHEMBL27910677 | 0.73 | POLB (0.50) | — | |
| SCHEMBL26388630 | 0.72 | POLB (0.34) | — | |
| SCHEMBL25552303 | 0.69 | LMNA (0.37) | — | |
| SCHEMBL6154432 | 0.69 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL25414795 | 0.69 | LRRK2 (0.40) | — | |
| SCHEMBL26032142 | 0.69 | CNR1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4401729-A1 | BCL-XL DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023044046-A1 | BCL-XL DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-23 | — | — | WO | disclosed |