Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872267 | 0.80 | ALDH1A1 (0.49) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL2246161 | 0.80 | ALDH1A1 (0.49) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL26979071 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL29172709 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL25311278 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL25206305 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL2241875 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL9872166 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAPKMMAPTATM | |
| SCHEMBL7849587 | 0.78 | KMT2A (0.50) | ALDH1A1GAAPKMSMN1; SMN2KMT2A | |
| SCHEMBL23250068 | 0.78 | ALDH1A1 (0.47) | ALDH1A1GAAPKMMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4401729-A1 | BCL-XL DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023044046-A1 | BCL-XL DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-23 | — | — | WO | disclosed |