SCHEMBL9872267

SCHEMBL9872267

Cc1ccc(S(=O)(=O)OCCCCOCc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.49
GAA P10253 1/20 0.49
PKM P14618 1/20 0.49
LMNA P02545 2/20 0.45
AR P10275 1/20 0.44
ATM Q13315 2/20 0.44
MAPT P10636 2/20 0.44
CYP24A1 Q07973 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
CA12 O43570 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CA9 Q16790 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
FKBP1A P62942 1/20 0.42
MCHR1 Q99705 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
PIR O00625 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25206305 0.99 ALDH1A1 (0.48) ALDH1A1GAAPKMLMNAAR
SCHEMBL26979071 0.99 ALDH1A1 (0.48) ALDH1A1GAAPKMLMNAAR
SCHEMBL2241875 0.99 ALDH1A1 (0.48) ALDH1A1GAAPKMLMNAAR
SCHEMBL29172709 0.99 ALDH1A1 (0.48) ALDH1A1GAAPKMLMNAAR
SCHEMBL9872166 0.99 ALDH1A1 (0.48) ALDH1A1GAAPKMLMNAAR
SCHEMBL2246161 0.97 ALDH1A1 (0.49) ALDH1A1GAAPKMLMNAAR
SCHEMBL18428703 0.96 ALDH1A1 (0.47) ALDH1A1GAAPKMLMNAAR
SCHEMBL25311278 0.96 ALDH1A1 (0.48) ALDH1A1GAAPKMLMNAAR
SCHEMBL23250068 0.94 ALDH1A1 (0.47) ALDH1A1GAAPKMLMNAAR
SCHEMBL21405231 0.94 ALDH1A1 (0.47) ALDH1A1GAAPKMLMNAAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES UNIV YALE (US) 2026-04-30 US disclosed
US-11986531-B2 Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides ARVINAS OPERATIONS, INC. (US) 2024-05-21 US disclosed
US-11964945-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2024-04-23 US disclosed
US-11952347-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2024-04-09 US disclosed
WO-2024054954-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. (US) 2024-03-14 WO disclosed
US-20240059686-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. (US) 2024-02-22 US disclosed
CN-117510491-A Compounds and methods for rapid accelerated targeted degradation of fibrosarcoma polypeptides 阿尔维纳斯运营股份有限公司 2024-02-06 CN disclosed
EP-3512842-B1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS INC (US) 2024-01-17 EP disclosed
US-20230357134-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS UCL BUSINESS LTD (GB) 2023-11-09 US disclosed
US-20230331681-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2023-10-19 US disclosed
US-20180179183-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES ARVINAS OPERATIONS, INC. 2018-06-28 US disclosed
US-20180099940-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2018-04-12 US disclosed
WO-2018053354-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. (US) 2018-03-22 WO disclosed
US-20180072711-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS OPERATIONS, INC. 2018-03-15 US disclosed
CN-107428734-A Compounds and methods for targeted degradation of androgen receptors 阿尔维纳斯股份有限公司 2017-12-01 CN disclosed
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2017-11-16 US disclosed
US-20160214972-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2016-07-28 US disclosed
US-5070139-A PLATELET ACTIVATING FACTOR ANTAGONISTS, HYPOTENSIVES J. URIACH & CIA. S.A. (ES) 1991-12-03 US disclosed
US-4940706-A 2,4-disubstituted 1,3-dioxolanes and pharmaceutical use J. URIACH & CIA, S.A. (ES) 1990-07-10 US disclosed
EP-0312041-A2 2,4-Disubstituted 1,3-dioxolanes J. URIACH & CIA. S.A. (ES) 1989-04-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180179183-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES CRBN, ARAF, VHL ALDH1A1 2833/4885GAA 1531/4885PKM 3978/4885
US-20160214972-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ESRRA, MDM2 ALDH1A1 460/4885GAA 1291/4885PKM 2985/4885
US-20230331681-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ADRM1, CRBN ALDH1A1 798/4885GAA 1082/4885PKM 3679/4885
US-20180072711-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ESR1, GPER1, ESR2 ALDH1A1 1117/4885GAA 1316/4885PKM 2365/4885
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, MDM2, ESRRA ALDH1A1 514/4885GAA 1071/4885PKM 2962/4885
US-20180099940-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ADRM1, CRBN ALDH1A1 824/4885GAA 1094/4885PKM 3709/4885
US-20240059686-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR AR, VHL, MDM2 ALDH1A1 520/4885GAA 1379/4885PKM 2959/4885
US-11964945-B2 Compounds and methods for the targeted degradation of androgen receptor AR, ADRM1, CRBN ALDH1A1 824/4885GAA 1094/4885PKM 3709/4885
US-11952347-B2 Compounds and methods for the targeted degradation of androgen receptor AR, ADRM1, CRBN ALDH1A1 798/4885GAA 1082/4885PKM 3679/4885
US-20230357134-A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS TTR, C1R, APOB ALDH1A1 1891/4885GAA 202/4885PKM 3379/4885
US-11986531-B2 Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides CRBN, ARAF, VHL ALDH1A1 2833/4885GAA 1531/4885PKM 3978/4885
US-20260115296-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES CRBN, VHL, ADRM1 ALDH1A1 2777/4885GAA 2139/4885PKM 3637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.