Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | UGCG | Q16739 | 2/20 | 0.41 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26649093 | 0.89 | CHRM3 (0.44) | OPRM1OPRL1LTA4HCHRM3CHRM2 | |
| SCHEMBL4900900 | 0.86 | CHRM3 (0.44) | OPRM1OPRL1LTA4HCHRM3CHRM2 | |
| SCHEMBL22437368 | 0.83 | TSHR (0.47) | OPRM1OPRL1CHRM3CHRM2CHRM1 | |
| SCHEMBL4690044 | 0.81 | CHRM3 (0.42) | OPRM1LTA4HCHRM3CHRM2CHRM1 | |
| SCHEMBL3490325 | 0.76 | TSHR (0.47) | OPRM1CHRM3CHRM2CHRM1SLC6A2 | |
| SCHEMBL13545892 | 0.76 | ALDH1A1 (0.55) | OPRM1OPRL1MEN1KMT2AKDM4E | |
| SCHEMBL4690683 | 0.75 | CHRM3 (0.38) | OPRM1GBA1UGCGGBA2LTA4H | |
| SCHEMBL4687898 | 0.75 | TSHR (0.41) | OPRM1LTA4HCHRM3CHRM2CHRM1 | |
| SCHEMBL4909810 | 0.74 | OPRM1 (0.58) | OPRM1OPRL1MEN1KMT2AKDM4E | |
| SCHEMBL4905758 | 0.74 | OPRM1 (0.58) | OPRM1OPRL1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4401729-A1 | BCL-XL DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023044046-A1 | BCL-XL DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-23 | — | — | WO | disclosed |