SCHEMBL30201337

SCHEMBL30201337

O=C(O)c1ccc(-c2cccnc2)nc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LDHA P00338 2/20 0.74
MKNK1 Q9BUB5 4/20 0.67
MKNK2 Q9HBH9 4/20 0.67
P4HA1 P13674 2/20 0.63
P4HTM Q9NXG6 1/20 0.63
ALDH1A1 P00352 1/20 0.61
APP P05067 1/20 0.61
GAA P10253 1/20 0.61
HCAR3 P49019 1/20 0.61
HCAR2 Q8TDS4 1/20 0.61
KMO O15229 2/20 0.58
CYP2A6 P11509 3/20 0.57
CYP3A4 P08684 1/20 0.57
BAZ2B Q9UIF8 1/20 0.51
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
ABL1 P00519 1/20 0.49
BCR P11274 1/20 0.49
PRKCA P17252 1/20 0.49
HDAC2 Q92769 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3203644 1.00 LDHA (0.74) LDHAMKNK1MKNK2P4HA1P4HTM
SCHEMBL12348489 0.89 LDHA (0.59) LDHAMKNK1MKNK2P4HA1P4HTM
SCHEMBL505455 0.85 LDHA (1.00) LDHAP4HA1P4HTMHCAR3BAZ2B
SCHEMBL29915944 0.85 MKNK1 (0.68) LDHAMKNK1MKNK2CYP2A6CYP3A4
SCHEMBL22578364 0.85 MKNK1 (0.68) LDHAMKNK1MKNK2CYP2A6CYP3A4
Hydrochloric Acid SCHEMBL18045639 0.84 LDHA (0.96) LDHAP4HA1P4HTMHCAR3BAZ2B
SCHEMBL5734988 0.82 LDHA (0.73) LDHAP4HA1P4HTMALDH1A1APP
SCHEMBL503140 0.82 LDHA (0.79) LDHAP4HA1P4HTMKMOBAZ2B
SCHEMBL3232965 0.82 MKNK1 (0.66) LDHAMKNK1MKNK2ALDH1A1APP
SCHEMBL8521766 0.81 LDHA (0.85) LDHAP4HA1P4HTMALDH1A1HCAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4376841-A1 PYRROLO[2,3-B]PYRIDINE PGDH INHIBITORS AND METHODS OF MAKING AND USING Epirium Bio Inc. (US) 2024-06-05 EP disclosed
WO-2023009642-A1 PYRROLO[2,3-B]PYRIDINE PGDH INHIBITORS AND METHODS OF MAKING AND USING EPIRIUM BIO INC. (US) 2023-02-02 WO disclosed