SCHEMBL30201378

SCHEMBL30201378

O=C(NC1C[C@H]2CC[C@@H](C1)N2Cc1ccc(F)cc1)c1ccc2cc[nH]c2c1

nearest known ligand 0.73

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 2/20 0.61
MEN1 O00255 1/20 0.59
KMT2A Q03164 1/20 0.59
CCR3 P51677 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30201412 0.91 CXCR6 (0.55) OPRK1MEN1KMT2A
SCHEMBL30201364 0.90 MEN1 (0.64) OPRK1MEN1KMT2A
SCHEMBL30201422 0.89 DRD4 (0.53) OPRK1MEN1KMT2A
SCHEMBL30201517 0.89 SMYD3 (0.52) OPRK1
SCHEMBL30201472 0.88 MEN1 (0.52) MEN1KMT2A
SCHEMBL30201509 0.83 DRD4 (0.55) MEN1KMT2ACCR3
SCHEMBL24950984 0.80 MAPT (0.58) MEN1KMT2A
SCHEMBL30201525 0.80 MAPT (0.58) MEN1KMT2A
SCHEMBL24950982 0.80 SMYD3 (0.48)
SCHEMBL30201410 0.80 SMYD3 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4376818-B1 SEROTONIN 5-HT2B INHIBITORY COMPOUNDS ZOETIS SERVICES LLC (US) 2025-06-18 EP claimed
WO-2023009330-A1 SEROTONIN 5-HT2B INHIBITORY COMPOUNDS ZOETIS SERVICES LLC (US) 2023-02-02 WO claimed
WO-2023009330-A1 SEROTONIN 5-HT2B INHIBITORY COMPOUNDS ZOETIS SERVICES LLC (US) 2023-02-02 WO disclosed