Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.48 |
| ▸ | GRM5 | P41594 | 9/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25143682 | 1.00 | WNT3A (0.48) | WNT3AGRM1GRM5PRMT5BTK | |
| SCHEMBL23301215 | 0.92 | NAMPT (0.49) | GRM1GRM5PRMT5BTKPDK4 | |
| SCHEMBL31443829 | 0.89 | PDK4 (0.46) | WNT3AGRM1GRM5PRMT5BTK | |
| SCHEMBL31607858 | 0.88 | PDK4 (0.47) | GRM1GRM5PRMT5BTKPDK4 | |
| SCHEMBL25205703 | 0.87 | PRMT5 (0.40) | WNT3AGRM1GRM5PRMT5BTK | |
| SCHEMBL30441835 | 0.87 | PRMT5 (0.40) | WNT3AGRM1GRM5PRMT5BTK | |
| SCHEMBL31630894 | 0.87 | PDK4 (0.45) | GRM1GRM5BTKPDK4NAMPT | |
| SCHEMBL29197745 | 0.87 | PDK4 (0.45) | GRM1GRM5BTKPDK4NAMPT | |
| SCHEMBL31444184 | 0.87 | BTK (0.47) | WNT3AGRM1GRM5PRMT5BTK | |
| SCHEMBL31583819 | 0.87 | GRM5 (0.46) | WNT3AGRM1GRM5BTKPDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430052-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| EP-4367118-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | Nurix Therapeutics, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |