Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 5/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25205703 | 1.00 | PRMT5 (0.40) | PRMT5GPR119WNT3ANAMPTGRM5 | |
| SCHEMBL30201557 | 0.87 | WNT3A (0.48) | PRMT5GPR119WNT3ANAMPTGRM5 | |
| SCHEMBL25143682 | 0.87 | WNT3A (0.48) | PRMT5GPR119WNT3ANAMPTGRM5 | |
| SCHEMBL25074365 | 0.80 | RET (0.40) | PRMT5GPR119GRM5ALDH1A1TSHR | |
| SCHEMBL23301215 | 0.80 | NAMPT (0.49) | PRMT5GPR119NAMPTGRM5GRM1 | |
| SCHEMBL25200347 | 0.79 | GPR119 (0.40) | GPR119GRM5 | |
| SCHEMBL25192135 | 0.78 | GPR119 (0.39) | PRMT5GPR119GRM5ALDH1A1ALOX15 | |
| SCHEMBL25199491 | 0.78 | GPR119 (0.43) | PRMT5GPR119GRM5 | |
| SCHEMBL31443829 | 0.77 | PDK4 (0.46) | PRMT5GPR119WNT3ANAMPTGRM5 | |
| SCHEMBL25190804 | 0.77 | PRMT5 (0.41) | PRMT5GPR119ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430052-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |