Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21724991 | 1.00 | IRAK4 (0.47) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2182279 | 0.87 | KCNH2 (0.48) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL27093000 | 0.86 | MAPK1 (0.46) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30906007 | 0.86 | MAPK1 (0.46) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30201761 | 0.82 | OPRK1 (0.46) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL21724833 | 0.82 | OPRK1 (0.46) | IRAK4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1693608 | 0.81 | PDE4B (0.58) | IRAK4MAPK1PDE4B | |
| SCHEMBL31678736 | 0.81 | MAPK3 (0.48) | IRAK4MAPK1MAPK3 | |
| SCHEMBL31678648 | 0.81 | MAPK3 (0.48) | IRAK4MAPK1MAPK3 | |
| SCHEMBL15749109 | 0.80 | MAPK1 (0.50) | IRAK4HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367118-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | Nurix Therapeutics, Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023023255-A1 | BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-02-23 | — | — | WO | disclosed |