Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.46 |
| ▸ | GABRP | O00591 | 3/20 | 0.46 |
| ▸ | GABRD | O14764 | 3/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.46 |
| ▸ | GABRE | P78334 | 3/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927215 | 1.00 | LMNA (0.62) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30202032 | 0.88 | LMNA (0.65) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927216 | 0.88 | LMNA (0.65) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927214 | 0.88 | LMNA (0.49) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881521 | 0.86 | GABRA1 (0.62) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30203044 | 0.86 | GABRA1 (0.62) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23952874 | 0.86 | LMNA (0.62) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30202195 | 0.84 | LMNA (0.60) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927177 | 0.84 | LMNA (0.60) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23927111 | 0.83 | LMNA (0.45) | LMNAGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019742-A | Novel benzodiazepine derivatives as GABA Aγ1 PAM | 豪夫迈·罗氏有限公司 | 2024-05-10 | — | — | CN | disclosed |
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |