Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 11/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927168 | 1.00 | APLNR (0.42) | APLNRSMN1; SMN2ALDH1A1LMNACYP11B1 | |
| SCHEMBL23927125 | 0.86 | CYP11B2 (0.38) | APLNRALDH1A1LMNACYP11B1CYP11B2 | |
| SCHEMBL30202070 | 0.86 | CYP11B2 (0.38) | APLNRALDH1A1LMNACYP11B1CYP11B2 | |
| SCHEMBL30202086 | 0.85 | SMN1; SMN2 (0.38) | APLNRSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL23927195 | 0.85 | SMN1; SMN2 (0.38) | APLNRSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL23927154 | 0.83 | SMN1; SMN2 (0.37) | APLNRSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL23927209 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1LMNAHPGDPTAFR | |
| SCHEMBL23927130 | 0.74 | PTAFR (0.35) | SMN1; SMN2ALDH1A1LMNAHPGDPTAFR | |
| SCHEMBL23927162 | 0.73 | PTAFR (0.36) | SMN1; SMN2LMNAHPGDPTAFR | |
| SCHEMBL30201932 | 0.73 | PTAFR (0.36) | SMN1; SMN2LMNAHPGDPTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | claimed |
| CN-115667262-A | Benzodiazepine derivatives as GABAA γ 1PAM | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| EP-4139310-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | disclosed |
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| CN-115667262-A | Benzodiazepine derivatives as GABAA γ 1PAM | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |