Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.31 |
| ▸ | CHUK | O15111 | 3/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30205937 | 1.00 | IKBKB (0.31) | IKBKBCHUKCCNCCDK8SYK | |
| Formic Acid SCHEMBL30206363 | 1.00 | IKBKB (0.31) | IKBKBCHUKCCNCCDK8SYK | |
| SCHEMBL29173707 | 0.96 | IKBKB (0.33) | IKBKBCHUKCCNCCDK8SYK | |
| SCHEMBL30802785 | 0.96 | IKBKB (0.33) | IKBKBCHUKCCNCCDK8SYK | |
| SCHEMBL30206535 | 0.86 | IKBKB (0.34) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| SCHEMBL30205980 | 0.86 | IKBKB (0.34) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| Formic Acid SCHEMBL30205928 | 0.80 | CCNC (0.34) | CCNCCDK8 | |
| Formic Acid SCHEMBL30206230 | 0.80 | CCNC (0.34) | CCNCCDK8 | |
| SCHEMBL29173737 | 0.79 | IKBKB (0.32) | IKBKBCHUKCCNCCDK8SYK | |
| SCHEMBL29173564 | 0.78 | IKBKB (0.34) | IKBKBCHUKSYKYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |