Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.33 |
| ▸ | CHUK | O15111 | 4/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173707 | 1.00 | IKBKB (0.33) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| Formic Acid SCHEMBL30206200 | 0.96 | IKBKB (0.31) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| Formic Acid SCHEMBL30205937 | 0.96 | IKBKB (0.31) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| Formic Acid SCHEMBL30206363 | 0.96 | IKBKB (0.31) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| SCHEMBL30205980 | 0.90 | IKBKB (0.34) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| SCHEMBL30206535 | 0.90 | IKBKB (0.34) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| SCHEMBL29173737 | 0.82 | IKBKB (0.32) | IKBKBCHUKCCNCCDK8YTHDC1 | |
| SCHEMBL29173564 | 0.81 | IKBKB (0.34) | IKBKBCHUKYTHDC1SYKPDE4A | |
| SCHEMBL31195427 | 0.81 | DGAT1 (0.38) | CCNCCDK8SYK | |
| SCHEMBL29173574 | 0.80 | IKBKB (0.37) | IKBKBCHUKYTHDC1SYKPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |