Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 10/20 | 0.34 |
| ▸ | CHUK | O15111 | 8/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206087 | 0.88 | IKBKB (0.33) | IKBKBCHUKPDE4APDE4BPDE4C | |
| SCHEMBL29173609 | 0.88 | IKBKB (0.33) | IKBKBCHUKPDE4APDE4BPDE4C | |
| SCHEMBL29173737 | 0.88 | IKBKB (0.32) | IKBKBCHUKPDE4APDE4BPDE4C | |
| SCHEMBL24943828 | 0.82 | CDK2 (0.37) | IKBKBCHUKSYK | |
| SCHEMBL24944992 | 0.82 | SYK (0.33) | SYK | |
| SCHEMBL24944982 | 0.81 | TYK2 (0.37) | SYK | |
| SCHEMBL30205499 | 0.81 | TYK2 (0.37) | SYK | |
| SCHEMBL30802785 | 0.81 | IKBKB (0.33) | IKBKBCHUKPDE4APDE4BPDE4C | |
| SCHEMBL29173707 | 0.81 | IKBKB (0.33) | IKBKBCHUKPDE4APDE4BPDE4C | |
| SCHEMBL24944492 | 0.81 | MAP2K2 (0.34) | IKBKBCHUKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |