Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 4/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 7/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CCND3 | P30281 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 3/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30802776 | 0.84 | EML4 (0.55) | EML4ALKLCKJAK3SYK | |
| SCHEMBL18884550 | 0.82 | JAK3 (0.62) | EML4ALKLCKJAK3SYK | |
| SCHEMBL30802783 | 0.81 | SYK (0.52) | EML4ALKLCKJAK3SYK | |
| SCHEMBL29173494 | 0.80 | EML4 (0.58) | EML4ALKJAK3SYKAURKA | |
| SCHEMBL30206068 | 0.80 | EML4 (0.58) | EML4ALKJAK3SYKAURKA | |
| SCHEMBL30206185 | 0.80 | JAK2 (0.54) | EML4ALKSYKAURKACDK4 | |
| SCHEMBL29173352 | 0.78 | SYK (0.53) | EML4ALKSYKAURKACDK4 | |
| SCHEMBL30205943 | 0.78 | SYK (0.53) | EML4ALKSYKAURKACDK4 | |
| SCHEMBL13405489 | 0.77 | PIM1 (0.64) | EML4ALKSYKAURKACDK4 | |
| SCHEMBL30206344 | 0.77 | EML4 (0.56) | EML4ALKLCKJAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |