Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.62 |
| ▸ | LCK | P06239 | 7/20 | 0.62 |
| ▸ | BTK | Q06187 | 10/20 | 0.59 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18884637 | 0.94 | BTK (0.64) | JAK3LCKBTKSYK | |
| SCHEMBL18884551 | 0.91 | BTK (0.64) | JAK3LCKBTKSYK | |
| SCHEMBL23080930 | 0.89 | BTK (0.55) | JAK3LCKBTK | |
| SCHEMBL18296155 | 0.88 | LCK (0.73) | JAK3LCKBTKEML4ALK | |
| SCHEMBL21855202 | 0.88 | BTK (0.59) | JAK3LCKBTKSYK | |
| SCHEMBL21946319 | 0.88 | BTK (0.59) | JAK3LCKBTKSYK | |
| SCHEMBL25605387 | 0.88 | BTK (0.59) | JAK3LCKBTK | |
| SCHEMBL18884392 | 0.88 | JAK3 (0.69) | JAK3LCKBTKSYK | |
| SCHEMBL25605382 | 0.88 | BTK (0.62) | JAK3LCKBTKSYK | |
| SCHEMBL18884526 | 0.87 | JAK3 (0.65) | JAK3LCKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190100505-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2019-04-04 | — | — | US | disclosed |
| US-20180030027-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2018-02-01 | — | — | US | disclosed |
| US-9656988-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2017-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030027-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | JAK3 53/4885LCK 3/4885BTK 1/4885 |
| US-20190100505-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LYN, LCK | JAK3 60/4885LCK 3/4885BTK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.