Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.81 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | CPT1A | P50416 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CPT2 | P23786 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28943330 | 1.00 | TRPV1 (0.81) | TRPV1TRPM8CPT1APOLBUSP2 | |
| SCHEMBL28943332 | 1.00 | TRPV1 (0.81) | TRPV1TRPM8CPT1APOLBUSP2 | |
| SCHEMBL30212104 | 0.86 | TRPV1 (0.78) | TRPV1TRPM8CPT1APOLBCPT2 | |
| SCHEMBL28943279 | 0.86 | TRPV1 (0.78) | TRPV1TRPM8CPT1APOLBCPT2 | |
| SCHEMBL28943281 | 0.86 | TRPV1 (0.78) | TRPV1TRPM8CPT1APOLBCPT2 | |
| SCHEMBL28943298 | 0.84 | TRPV1 (1.00) | TRPV1CPT1APOLBCPT2KMT2A | |
| SCHEMBL28943294 | 0.84 | TRPV1 (1.00) | TRPV1CPT1APOLBCPT2KMT2A | |
| SCHEMBL28943401 | 0.83 | TRPV1 (0.82) | TRPV1CPT1APOLBCPT2MEN1 | |
| SCHEMBL28943403 | 0.83 | TRPV1 (0.82) | TRPV1CPT1APOLBCPT2MEN1 | |
| SCHEMBL28943377 | 0.83 | TRPV1 (0.81) | TRPV1CPT1APOLBCPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | disclosed |