Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24027843 | 1.00 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL25214857 | 0.84 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9429509 | 0.82 | SMN1; SMN2 (0.69) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30212894 | 0.82 | SMN1; SMN2 (0.69) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL22678507 | 0.81 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL29408140 | 0.81 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL22658259 | 0.79 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL24027840 | 0.79 | RXFP1 (0.54) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30255954 | 0.79 | RXFP1 (0.54) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL24027845 | 0.78 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149928-A1 | IMIDAZOLE 3-OXIDE DERIVATIVE BASED ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2023-03-22 | — | — | EP | disclosed |
| CN-115697974-A | Imidazole 3-oxide derivative based ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2023-02-03 | — | — | CN | disclosed |