Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22678507 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL30212894 | 0.89 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL9429509 | 0.89 | SMN1; SMN2 (0.69) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL22658259 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL24027824 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL30212830 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL8752439 | 0.82 | MEN1 (0.66) | MEN1KMT2AMAPTGAAALDH1A1 | |
| SCHEMBL30212852 | 0.81 | LMNA (0.50) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL24027843 | 0.81 | LMNA (0.50) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL17925886 | 0.81 | MEN1 (0.57) | SMN1; SMN2MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697974-A | Imidazole 3-oxide derivative based ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2023-02-03 | — | — | CN | disclosed |
| EP-3969439-A1 | ACSS2 INHIBITORS AND METHODS OF USE THEREOF | Metabomed Ltd (IL) | 2022-03-23 | — | — | EP | disclosed |
| CN-114127049-A | ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2022-03-01 | — | — | CN | disclosed |