Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17140845 | 0.86 | GPR119 (0.51) | KDM4EPKMTSHRALOX15ATM | |
| SCHEMBL30216692 | 0.83 | CASR (0.47) | ALOX15CASRHTR1AHTR7 | |
| SCHEMBL7082012 | 0.83 | CYP2D6 (0.59) | TSHRCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30216685 | 0.81 | CASR (0.44) | ALOX15CASRHTR1AHTR7 | |
| SCHEMBL30216705 | 0.80 | ABCB1 (0.41) | ALOX15CASRHTR1AHTR7 | |
| SCHEMBL30216675 | 0.79 | CASR (0.44) | ALOX15CASRHTR1AHTR7 | |
| SCHEMBL30216708 | 0.79 | CASR (0.42) | CASRHTR1AHTR7 | |
| SCHEMBL7084127 | 0.79 | GPR119 (0.49) | PKMGPR119USP30 | |
| SCHEMBL31117829 | 0.78 | MEN1 (0.51) | ANO1MEN1KMT2A | |
| SCHEMBL30216681 | 0.77 | GPR119 (0.40) | PARP14EPHX2ANO1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023049438-A1 | GRK2 INHIBITORS AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |