Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 5/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30216692 | 0.83 | CASR (0.47) | ABCB1ABCG2SLC7A5RAB9ABUB1 | |
| SCHEMBL30216685 | 0.82 | CASR (0.44) | ABCB1ABCG2SLC7A5RAB9ABUB1 | |
| SCHEMBL30216675 | 0.81 | CASR (0.44) | ABCB1ABCG2SLC7A5RAB9ABUB1 | |
| SCHEMBL30216708 | 0.81 | CASR (0.42) | ABCB1ABCG2SLC7A5RAB9ACASR | |
| SCHEMBL30216673 | 0.80 | PARP14 (0.49) | CASRHTR1AHTR7ALOX15 | |
| SCHEMBL27453091 | 0.71 | ALDH1A1 (0.56) | ABCB1ABCG2SLC7A5RAB9AF2 | |
| SCHEMBL13659673 | 0.71 | NPSR1 (0.69) | ABCB1ABCG2RAB9ANPC1MAPT | |
| Hydrogen Peroxide SCHEMBL27146001 | 0.71 | SLC7A5 (0.60) | ABCB1ABCG2SLC7A5RAB9AF2 | |
| SCHEMBL2025451 | 0.70 | SLC7A5 (0.51) | ABCB1ABCG2SLC7A5RAB9AF2 | |
| SCHEMBL23304322 | 0.69 | PKM (0.44) | ABCB1ABCG2SLC7A5RAB9AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023049438-A1 | GRK2 INHIBITORS AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |