Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.51 |
| ▸ | AKT2 | P31751 | 4/20 | 0.51 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12920734 | 0.83 | COMT (0.55) | AKT1AKT2F2RL1MAP3K14USP7 | |
| SCHEMBL21500652 | 0.78 | F2RL1 (0.56) | AKT1AKT2F2RL1NPC1RAB9A | |
| SCHEMBL25391 | 0.77 | F2RL1 (0.58) | AKT1AKT2F2RL1NPC1RAB9A | |
| SCHEMBL9611707 | 0.76 | ALDH1A1 (0.56) | USP7NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL15910846 | 0.75 | MAP3K14 (0.40) | AKT1AKT2MAP3K14USP7PIK3CD | |
| SCHEMBL30422705 | 0.74 | ALDH1A1 (0.40) | AKT1AKT2MAP3K14USP7PIK3CD | |
| SCHEMBL12920739 | 0.73 | ADORA3 (0.43) | AKT1AKT2F2RL1USP7NPC1 | |
| SCHEMBL15071104 | 0.73 | HPGD (0.52) | AKT1AKT2F2RL1NPC1RAB9A | |
| SCHEMBL15050025 | 0.73 | AKT1 (0.58) | AKT1AKT2F2RL1NPC1RAB9A | |
| SCHEMBL15071152 | 0.70 | F2RL1 (0.75) | F2RL1ALDH1A1HPGDSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117751117-A | SARM1 enzyme activity inhibitor and application thereof | 科辉智药生物科技（无锡）有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-115724839-A | SARM1 enzyme activity inhibitor and application thereof | 科辉智药生物科技(深圳)有限公司 | 2023-03-03 | — | — | CN | disclosed |
| WO-2023025244-A1 | SARM1 ENZYME ACTIVITY INHIBITOR AND APPLICATION THEREOF | 科辉智药生物科技(深圳)有限公司 | 2023-03-02 | — | — | WO | disclosed |