Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219731 | 1.00 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MAPTHPGDNPC1 | |
| SCHEMBL6490343 | 0.81 | MEN1 (0.60) | ALDH1A1SMN1; SMN2MAPTHPGDNPC1 | |
| SCHEMBL30219745 | 0.79 | RXFP1 (0.41) | SMN1; SMN2MAPTHPGDNPC1RAB9A | |
| SCHEMBL30219734 | 0.78 | RXFP1 (0.51) | SMN1; SMN2MAPTRXFP1MEN1KMT2A | |
| SCHEMBL24046641 | 0.77 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL30219722 | 0.77 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP2C19 | |
| SCHEMBL1948204 | 0.74 | RXFP1 (0.46) | MAPTRXFP1LMNAMAPK1CA12 | |
| SCHEMBL30042580 | 0.72 | RXFP1 (0.73) | ALDH1A1SMN1; SMN2MAPTRAB9ACYP2C19 | |
| SCHEMBL1013325 | 0.72 | RXFP1 (0.73) | ALDH1A1SMN1; SMN2MAPTRAB9ACYP2C19 | |
| SCHEMBL3650686 | 0.72 | RXFP1 (0.57) | SMN1; SMN2MAPTNPC1RAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153175-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |