Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25226689 | 1.00 | KDM4E (0.60) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL8606580 | 0.84 | ALDH1A1 (0.59) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL19420176 | 0.81 | MAPT (0.70) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL965053 | 0.79 | MAPT (0.70) | MAPTALDH1A1LMNAHTTGAA | |
| SCHEMBL968558 | 0.78 | LMNA (0.56) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL8788041 | 0.78 | ALDH1A1 (0.67) | KDM4EMAPTALDH1A1LMNAHTT | |
| Hydrochloric Acid SCHEMBL1358888 | 0.77 | MAPT (0.68) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL17122422 | 0.77 | MAPT (0.74) | MAPTALDH1A1LMNAHTTGAA | |
| SCHEMBL5142590 | 0.77 | MAPT (0.77) | MAPTALDH1A1HTTGAAKMT2A | |
| SCHEMBL31236338 | 0.77 | MAPT (0.77) | MAPTALDH1A1HTTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153175-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |