Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046638 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HPGDKMT2AMAPK1MEN1 | |
| SCHEMBL24495130 | 0.88 | ALDH1A1 (0.56) | ALDH1A1HPGDKMT2AMAPK1MEN1 | |
| SCHEMBL30219751 | 0.81 | POLB (0.50) | ALDH1A1HPGDKMT2AMAPK1MEN1 | |
| SCHEMBL24046633 | 0.81 | POLB (0.50) | ALDH1A1HPGDKMT2AMAPK1MEN1 | |
| SCHEMBL24046535 | 0.78 | CYP3A4 (0.44) | ALDH1A1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30219763 | 0.78 | CYP3A4 (0.44) | ALDH1A1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL24495325 | 0.75 | SMN1; SMN2 (0.72) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL24046562 | 0.74 | MAPT (0.58) | ALDH1A1HPGDKMT2AMAPK1MEN1 | |
| SCHEMBL11829260 | 0.73 | CPN1 (0.54) | ALDH1A1LMNASMN1; SMN2POLBKDM4E | |
| SCHEMBL3840269 | 0.72 | FNTA (0.63) | ALDH1A1HPGDMAPK1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153175-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |