Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521398 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL710108 | 0.95 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL21937028 | 0.89 | MAPT (0.51) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL20521289 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL8257373 | 0.84 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL31457120 | 0.84 | ALDH1A1 (0.60) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL30938985 | 0.84 | MAPT (0.52) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL20231932 | 0.84 | MAPT (0.52) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL20522058 | 0.84 | SMARCA2 (0.49) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL20668600 | 0.84 | MAPT (0.56) | SMN1; SMN2ALDH1A1MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115991679-A | 2-oxothiazole derivatives as A2A inhibitors and compounds for the treatment of cancer | 伊忒欧斯比利时股份公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115873022-A | 2-oxothiazole derivatives as A2A inhibitors and compounds for the treatment of cancer | 伊忒欧斯比利时股份公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-110678472-B | 2-oxothiazole derivatives as A2A inhibitors and compounds for the treatment of cancer | 伊忒欧斯比利时股份公司 | 2023-01-24 | — | — | CN | disclosed |