Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.46 |
| ▸ | AXL | P30530 | 3/20 | 0.41 |
| ▸ | ETV6 | P41212 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24073458 | 1.00 | HRH3 (0.46) | HRH3AXLETV6CYP2D6DRD2 | |
| SCHEMBL30266610 | 0.91 | HRH3 (0.40) | HRH3AXLETV6CYP2D6DRD2 | |
| SCHEMBL24073379 | 0.91 | HRH3 (0.40) | HRH3AXLETV6CYP2D6DRD2 | |
| SCHEMBL1953271 | 0.89 | HRH3 (0.49) | HRH3CYP2D6DRD2KCNH2GRIN2B | |
| SCHEMBL520119 | 0.88 | HRH3 (0.44) | HRH3AXLETV6GRIN2B | |
| SCHEMBL4768314 | 0.85 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL24740620 | 0.80 | GAA (0.43) | HRH3DRD2KCNH2GRIN2B | |
| SCHEMBL467492 | 0.79 | HTR1D (0.44) | HRH3AXLCYP2D6GRIN2B | |
| SCHEMBL19633006 | 0.79 | HTR1D (0.44) | HRH3AXLCYP2D6GRIN2B | |
| SCHEMBL17797651 | 0.79 | DRD2 (0.43) | HRH3CYP2D6DRD2KCNH2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697993-B | Pyrimidine compounds as AXL inhibitors | 南京正大天晴制药有限公司 | 2024-12-10 | — | — | CN | disclosed |
| EP-4163278-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. (CN) | 2023-04-12 | — | — | EP | disclosed |
| CN-115697993-A | Pyrimidines as AXL inhibitors | 南京正大天晴制药有限公司 | 2023-02-03 | — | — | CN | disclosed |