Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273312 | 1.00 | KMO (0.42) | KMOMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL16242291 | 0.81 | KMO (0.47) | KMOKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL29275465 | 0.80 | PARP10 (0.40) | MAPK14MAPK13MAPK12MAPK11PARP10 | |
| SCHEMBL28105602 | 0.80 | KMO (0.50) | KMOKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL15673169 | 0.80 | IDO1 (0.44) | MAPK14ACMSDIDO1ALOX5APFEN1 | |
| SCHEMBL16150623 | 0.79 | ADORA2A (0.41) | KMOKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL27664998 | 0.79 | LOXL2 (0.45) | MAPK14MAPK13MAPK12MAPK11PARP10 | |
| SCHEMBL2370541 | 0.79 | AAK1 (0.49) | GRM5 | |
| SCHEMBL26606822 | 0.79 | KMO (0.42) | KMOKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL4932513 | 0.77 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |