Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30392789 | 0.94 | RECQL (0.42) | RECQLCYP1A2KMOADRA2AP2RX7 | |
| SCHEMBL23993150 | 0.86 | RECQL (0.56) | RECQLCYP1A2KMOADRA2AP2RX7 | |
| SCHEMBL29989569 | 0.73 | CYP17A1 (0.44) | RECQLCYP1A2KMOCYP17A1HTR2A | |
| SCHEMBL29355368 | 0.73 | CYP1A2 (0.45) | RECQLCYP1A2KMOADRA2AP2RX7 | |
| SCHEMBL29353804 | 0.73 | CRHR1 (0.42) | RECQLCYP1A2KMOADRA2ANPC1 | |
| SCHEMBL29487730 | 0.71 | RECQL (0.46) | RECQLCYP1A2KMOADRA2AP2RX7 | |
| SCHEMBL25434947 | 0.71 | CYP1A2 (0.36) | RECQLCYP1A2CYP17A1HTR2AHTR2C | |
| SCHEMBL30896807 | 0.71 | HTR2A (0.42) | KMOADRA2AHTR2AHTR2C | |
| SCHEMBL23994190 | 0.71 | KMO (0.55) | CYP1A2KMOADRA2ACYP17A1HTR2A | |
| SCHEMBL24338531 | 0.71 | KMO (0.55) | CYP1A2KMOADRA2ACYP17A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |