Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228174 | 0.88 | NPC1 (0.57) | NPC1RAB9AKMT2AMEN1ATM | |
| SCHEMBL30228274 | 0.84 | CA12 (0.70) | CA12CA9CA1NPC1RAB9A | |
| SCHEMBL30228520 | 0.80 | CA12 (0.65) | CA12CA9KMT2AMEN1KCNA3 | |
| SCHEMBL27657088 | 0.78 | KCNA3 (0.59) | CA12CA9NPC1RAB9AKMT2A | |
| SCHEMBL17786392 | 0.75 | KDM4E (0.65) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL30449676 | 0.74 | CA12 (1.00) | CA12CA9CA1NPC1RAB9A | |
| SCHEMBL8516165 | 0.74 | CA12 (1.00) | CA12CA9CA1NPC1RAB9A | |
| SCHEMBL17786504 | 0.74 | CYP3A4 (0.63) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL30228151 | 0.73 | HPGD (0.73) | CA12CA9CA1NPC1RAB9A | |
| SCHEMBL30228334 | 0.72 | RAB9A (0.60) | CA12CA9CA1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |