Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711159 | 1.00 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL30228191 | 0.91 | MAPT (0.55) | ALDH1A1HPGDMAPTKDM4ENPSR1 | |
| SCHEMBL30227919 | 0.89 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL30227915 | 0.80 | ALDH1A1 (0.64) | ALDH1A1HPGDMAPTKDM4EKMT2A | |
| SCHEMBL21629644 | 0.77 | ALDH1A1 (0.60) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL20839111 | 0.76 | CYP3A4 (0.61) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL30055582 | 0.76 | CYP3A4 (0.61) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL20839108 | 0.76 | CYP3A4 (0.61) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL30228241 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTKDM4EHTT | |
| SCHEMBL30228252 | 0.76 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |