Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228063 | 0.89 | CA12 (0.46) | CA12CA9ESR1KCNA3TDP1 | |
| SCHEMBL30228096 | 0.81 | CA12 (0.48) | CA12CA9KCNA3TDP1MEN1 | |
| SCHEMBL20839408 | 0.81 | CA12 (0.69) | CA12CA9ESR1KMT2AKDM4E | |
| SCHEMBL30227956 | 0.81 | CA12 (0.48) | CA12CA9ESR1KCNA3TDP1 | |
| SCHEMBL30228226 | 0.81 | CA12 (0.69) | CA12CA9ESR1KMT2AKDM4E | |
| SCHEMBL30228177 | 0.81 | KDM4E (0.49) | CA12CA9ESR1KCNA3TDP1 | |
| SCHEMBL31089799 | 0.79 | CA12 (0.51) | CA12CA9KCNA3KDM4EALDH1A1 | |
| SCHEMBL30228180 | 0.78 | CA12 (0.46) | CA12CA9ESR1KCNA3TDP1 | |
| SCHEMBL30227943 | 0.78 | CA12 (0.45) | CA12CA9ESR1KCNA3TDP1 | |
| SCHEMBL30228316 | 0.78 | SLC18A1 (0.47) | CA12CA9KCNA3TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |