Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.45 |
| ▸ | MC4R | P32245 | 3/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228304 | 1.00 | DPP4 (0.45) | DPP4DPP7MC4RGRM2CA12 | |
| SCHEMBL30228318 | 1.00 | DPP4 (0.45) | DPP4DPP7MC4RGRM2CA12 | |
| SCHEMBL30228087 | 0.90 | PRSS1 (0.42) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30228057 | 0.90 | PRSS1 (0.42) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL31710454 | 0.90 | PRSS1 (0.42) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL31711008 | 0.90 | PRSS1 (0.42) | DPP4DPP7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30228025 | 0.86 | ALDH1A1 (0.46) | KDM4EALDH1A1 | |
| SCHEMBL30228018 | 0.86 | ALDH1A1 (0.46) | KDM4EALDH1A1 | |
| SCHEMBL30228283 | 0.86 | ALDH1A1 (0.46) | KDM4EALDH1A1 | |
| SCHEMBL30228404 | 0.85 | CA12 (0.41) | GRM2CA12CA9HSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |