Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228076 | 0.89 | CA12 (0.39) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228122 | 0.89 | HPGD (0.40) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228038 | 0.89 | CA12 (0.39) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228345 | 0.89 | CA12 (0.39) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30227928 | 0.88 | ALDH1A1 (0.41) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228318 | 0.85 | DPP4 (0.45) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228393 | 0.85 | DPP4 (0.45) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228304 | 0.85 | DPP4 (0.45) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL30228052 | 0.82 | CA12 (0.48) | CA12CA9ESR1ALDH1A1HPGD | |
| SCHEMBL31710454 | 0.81 | PRSS1 (0.42) | ALDH1A1SMN1; SMN2MAPK14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |