SCHEMBL3023293

SCHEMBL3023293

CNCCC#Cc1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 8/20 1.00
CHRNA4 P43681 8/20 1.00
CYP2A6 P11509 4/20 0.73
CYP2C9 P11712 4/20 0.73
CYP2C19 P33261 4/20 0.73
CYP2B6 P20813 3/20 0.73
CYP2D6 P10635 3/20 0.57
CYP2E1 P05181 2/20 0.57
CYP3A4 P08684 2/20 0.57
CYP1A2 P05177 1/20 0.56
CYP2C8 P10632 1/20 0.56
GRM5 P41594 2/20 0.44
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43
DRD3 P35462 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
MEN1 O00255 1/20 0.43
ALOX15 P16050 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3613286 0.84 CYP2A6 (1.00) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL14085289 0.81 CHRNB2 (0.69) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL3044684 0.79 CHRNB2 (0.70) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL22727562 0.78 CHRNB2 (0.64) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL3673693 0.78 CHRNB2 (0.69) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL4065112 0.77 CHRNB2 (0.63) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL14085349 0.77 CYP2A6 (0.73) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL5376053 0.77 CHRNB2 (0.63) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL7052162 0.77 CYP2A6 (0.68) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19
SCHEMBL3064618 0.77 CHRNB2 (0.67) CHRNB2CHRNA4CYP2A6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3899126-B2 2007-03-28 JP claimed
EP-0873050-B1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS TARGACEPT INC (US) 2004-03-10 EP claimed
JP-2001520628-A 2001-10-30 JP claimed
EP-0801527-A4 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS REYNOLDS TOBACCO CO R (US) 2001-09-05 EP claimed
US-6107298-A ADMINISTERING AN AMINE SUBSTITUTED PYRIMIDINE OR PYRIDINE COMPOUND BENCHERIF MEROUANE (US) 2000-08-22 US claimed
EP-0873050-A4 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS REYNOLDS TOBACCO CO R (US) 1999-09-22 EP claimed
US-5885998-A ADMINISTERING AN EFFECTIVE AMOUNT OF AN ARYL SUBSISTITUTED ALIPHATIC COMPOUND, AN ARYL SUBSTITUTED OLEFINIC AMINE COMPOUND OR AN ARYL SUBSTITUTED ACETYLENIC COMPOUND SUCH AS 4-(5-PYRIMIDINYL)-3-BUTENE-1-AMINE TARGACEPT, INC., A CORPORATION OF DELAWARE 1999-03-23 US claimed
EP-0873050-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS R.J. REYNOLDS TOBACCO COMPANY (US) 1998-10-28 EP claimed
US-5824692-A AMINOPYRIDINE, AMINOPYRIMIDINE DERIVATIVES TARGACEPT, INC. 1998-10-20 US claimed
EP-0801646-A4 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS REYNOLDS TOBACCO CO R (US) 1998-03-25 EP claimed
US-5731314-A ADMINISTERING ARYL SUBSTITUTED OLEFINIC AMINE COMPOUNDS OR ARYL SUBSTITUTED ACETYLENIC AMINE COMPOUNDS TO A PATIENT TARGACEPT, INC., A CORPORATION OF DELAWARE 1998-03-24 US claimed
EP-0801646-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1997-10-22 EP claimed
EP-0801527-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1997-10-22 EP claimed
US-5616707-A N-METHYL-4-PYRIDYL-3-BUT(ENE OR YNE)-1-AMINE TARGACEPT, INC. 1997-04-01 US claimed
US-5604231-A NON-STEROIDAL ANTIINFLAMMATORY AGENTS, DOPAMINERGIC AGENTS; SIDE EFFECT REDUCTION TARGACEPT, INC. 1997-02-18 US claimed
WO-1996020929-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO claimed
WO-1996020600-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO claimed
WO-1996020599-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF ULCERATIVE COLITIS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO claimed
US-8288420-B2 Compounds capable of activating cholinergic receptors TARGACEPT, INC. (US) 2012-10-16 US disclosed
WO-1996020929-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1996-07-11 WO disclosed