Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23884122 | 1.00 | PTPN1 (0.37) | PTPN1HTR7HTR1AMAPTL3MBTL1 | |
| SCHEMBL1606856 | 0.86 | PTPN1 (0.42) | PTPN1MAPTL3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL2046409 | 0.81 | SMN1; SMN2 (0.44) | PTPN1MAPTL3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL9082172 | 0.81 | PTPN1 (0.39) | PTPN1HTR7MAPTL3MBTL1HPGD | |
| SCHEMBL29572501 | 0.80 | HTR7 (0.53) | HTR7HTR1AMAPTL3MBTL1HPGD | |
| SCHEMBL755670 | 0.80 | HTR7 (0.53) | HTR7HTR1AMAPTL3MBTL1HPGD | |
| SCHEMBL6564781 | 0.79 | PTPN1 (0.41) | PTPN1HTR7MAPTL3MBTL1HPGD | |
| SCHEMBL6932234 | 0.79 | PTPN1 (0.49) | PTPN1HTR1AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL17919290 | 0.79 | PTPN1 (0.45) | PTPN1HTR7MAPTL3MBTL1HPGD | |
| SCHEMBL4054307 | 0.78 | CA1 (0.46) | MAPTL3MBTL1HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916748-A | Indole derivatives as alpha-1 antitrypsin modulators for the treatment of alpha-1 antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-4132908-A1 | INDOLE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD) | Vertex Pharmaceuticals Incorporated (US) | 2023-02-15 | — | — | EP | disclosed |