Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 11/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867477 | 0.84 | POLB (0.52) | POLBNPC1CASP6MEN1KMT2A | |
| SCHEMBL30234578 | 0.84 | POLB (0.52) | POLBNPC1CASP6MEN1KMT2A | |
| SCHEMBL23859942 | 0.75 | POLB (0.55) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL23867525 | 0.74 | HTR2A (0.49) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL23867516 | 0.72 | POLB (0.53) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL23867475 | 0.71 | POLB (0.55) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL30979648 | 0.68 | POLB (0.66) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL23867550 | 0.68 | POLB (0.76) | POLBNPC1CASP6MEN1KMT2A | |
| SCHEMBL23867511 | 0.68 | PYGM (0.53) | NPC1ALDH1A1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL23867479 | 0.66 | POLB (0.49) | POLBNPC1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |