Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23859942 | 0.92 | POLB (0.55) | POLBRAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL23867551 | 0.88 | LMNA (0.61) | POLBRAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL23867479 | 0.87 | POLB (0.49) | POLBRAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL23867487 | 0.82 | MAPT (0.67) | POLBMAPTLMNAHSD17B10ALDH1A1 | |
| SCHEMBL23867576 | 0.81 | LMNA (0.52) | POLBMAPTSMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL30234299 | 0.77 | LMNA (0.65) | POLBMAPTLMNAHSD17B10ALDH1A1 | |
| SCHEMBL31094221 | 0.77 | LMNA (0.49) | POLBMAPTSMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL23867508 | 0.76 | ALDH1A1 (0.55) | RAB9AMAPTSMN1; SMN2NPC1LMNA | |
| SCHEMBL23867475 | 0.76 | POLB (0.55) | POLBRAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL972202 | 0.75 | POLB (0.57) | POLBRAB9AMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118338898-A | Small molecule inhibitors of oncogenic CHD1L with preclinical anti-colorectal cancer activity | 科罗拉多州立大学董事会（法人团体） | 2024-07-12 | — | — | CN | disclosed |